Chromosome segregation: how to open cohesin without cutting the ring?
نویسندگان
چکیده
Chromosome segregation is triggered when the ring-shaped chromosomal cohesin complex is opened by proteolytic cleavage to release pairs of sister chromatids. Even before this dramatic event in anaphase, many cohesin rings lead a dynamic life on chromosomes, and in metazoan cells a good part of them dissociate from chromosome arms during mitotic prophase. Two new papers in The EMBO Journal address how chromatin can get into and out of the cohesin ring without requiring its cleavage.
منابع مشابه
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ورودعنوان ژورنال:
- The EMBO journal
دوره 32 5 شماره
صفحات -
تاریخ انتشار 2013